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Temazepam might minimize the excretion amount of Acetaminophen which could end in a greater serum degree.apalutamide will minimize the extent or outcome of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with drugs which have been CYP2C19 subs